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Absolutely. In fact, it is consumed with low amounts or no DMT-containing admixtures in many Amazonian communities. This is quite common for more communal ceremonies, as the DMT-rich brews can be overwhelming for non-shamanic members.

Also, the purging element of ayahuasca holds a much higher importance in some communities, where a weakly visionary but highly emetic version of the brew is drunk in public rituals for the cleansing of the body; the brew itself is endearingly referred to as la purga.